PLANTS: No NAT genes
identified to date |
Taxon |
Organism scientific name(c) |
Organism identification code |
Taxonomy identifier |
Gene |
ORF (nt) |
Protein (aa) |
Exon span |
Number of introns |
Locus tag |
TPA accession number |
Rhizaria (1) |
None |
|
|
|
|
|
|
|
|
|
Cryptophyta (2) |
None |
|
|
|
|
|
|
|
|
|
Heterolobosea (1) |
Naegleria gruberi NEG-M |
NAEGR |
NAT1 |
969 |
322 |
1 (1-969) |
0 |
|||
NAT2 |
990 |
329 |
1 (1-990) |
0 |
||||||
Amoebozoa (5) |
Entamoebidae (3) |
|||||||||
None |
|
|
|
|
|
|
|
|
|
|
Dictyosteliida (2) |
||||||||||
Dictyostelium
discoideum AX4 |
DICDI |
NAT1 |
921 |
306 |
1 (1-310) 2 (410-1020) |
1 |
||||
NAT2 |
978 |
325 |
1 (1-301) 2 (415-1091) |
1 |
||||||
NAT3 |
900 |
299 |
1 (1-310) 2 (402-991) |
1 |
||||||
NAT4 |
837 |
278 |
1 (1-837) |
0 |
||||||
NAT5 |
870 |
289 |
1 (1-870) |
0 |
||||||
NAT6 |
1464 |
487 |
1 (1-256) 2 (324-784) 3 (1959-2220) 4 (2321-2776) 5 (2805-2833) |
4 |
||||||
Polysphondylium
pallidum PN500 |
POLPA |
NAT1 |
822 |
273 |
1 (1-822) |
0 |
||||
NAT2 |
777 |
258 |
1 (1-562) 2 (623-837) |
1 |
||||||
Parabasalia (1) |
None |
|
|
|
|
|
|
|
|
|
Stramenopiles (7) |
Oomycetes (5) |
|||||||||
Saprolegnia parasitica CBS 223.65 |
SAPPC |
NAT1 |
951 |
316 |
1 (1-951) |
0 |
|
|||
NAT2 |
933 |
310 |
1 (1-933) |
0 |
|
|||||
Bacillariophyta (diatoms) (2) |
||||||||||
Phaeodactylum
tricornutum CCAP 1055/1 |
PHATR |
|
NAT1 |
981 |
326 |
1 (1-981) |
0 |
|
||
Alveolata (18) |
Perkinsea (1) |
|||||||||
None |
|
|
|
|
|
|
|
|
|
|
Apicomplexa (15) |
||||||||||
None |
|
|
|
|
|
|
|
|
|
|
Ciliophora (2) |
||||||||||
Paramecium tetraurelia d4-2 |
PARTE |
NAT1 |
861 |
286 |
1 (1-861) |
0 |
||||
NAT2 |
861 |
286 |
1 (1-861) |
0 |
||||||
NAT3 |
867 |
288 |
1 (1-867) |
0 |
||||||
NAT4 |
441 |
146 |
1 (441) |
0 |
||||||
Tetrahymena thermophila SB210 |
TETTH |
NAT1 |
858 |
285 |
1 (1-858) |
0 |
||||
NAT2 |
873 |
290 |
1 (1-873) |
0 |
||||||
NAT3 |
885 |
294 |
1 (1-491) 2 (605-758) 3 (1905-2001) 4 (2276-2418) |
3 |
|
|||||
NAT4 |
861 |
286 |
1 (1-861) |
0 |
||||||
NAT5 |
858 |
285 |
1 (1-858) |
0 |
||||||
NAT6 |
843 |
280 |
1 (1-843) |
0 |
||||||
Fornicata (1) |
None |
|
|
|
|
|
|
|
|
|
Euglenozoa (5) |
None |
|
|
|
|
|
|
|
|
|
Ichthyosporea (1) |
None |
|
|
|
|
|
|
|
|
|
Choanoflagellida (1) |
Monosiga brevicollis MX1 |
MONBE |
NAT1 |
1029 |
342 |
1 (1-1029) |
0 |
|||
Chlorophyta (2) |
Chlamydomonas
reinhardtii CC-503 cw92 mt+ |
CHLRE |
NAT1 |
924 (partial 3' end) |
308 (partial C-terminus) |
1 (1-99) 2 (390-470) 3 (757-822) 4 (1639-1698) 5 (1862-1942) 6 (2429-2491) 7 (3163-3255) 8 (3760-3821) 9 (4573-4704) 10 (5094-5118) 11 (5911-6051) 12 (6339-6504) 13 (7099-7145) |
12 |
(a) The details and
provisional taxonomic classification of the sequenced genomes of protist
species are available on http://www.ncbi.nlm.nih.gov/genomes/leuks.cgi. The term
"protists" is used to describe a diverse range of lower eukaryotic
organisms and does not refer to any particular monophyletic taxonomic group (http://www.discoverlife.org/mp/20m?tree=Protists&res=1000). The
appropriate reference sequence for each taxonomic group of protists should be requested from the NAT Gene Nomenclature
Committee.
(b) Column
key – Columns 1, 2: The numbers in brackets are sequenced genomes of
protist species accessible via BLAST (2010); Columns 2-4: The
scientific name, official identification code and unique taxonomy identifier
for each organism are available from the UniProt Taxonomy Browser (http://www.uniprot.org/taxonomy/); Columns 5-9:
The retrieval and annotation of NAT-homologous sequences (ORF
span and exon-intron structure) were carried out as described [41], and the gene symbols were assigned according to
the guidelines of the NAT Gene Nomenclature
Committee. The sequence length of open reading frames (ORF) is shown in nucleotides (nt) and of deduced proteins in amino acids (aa); Column 10:
Where available, the locus tags are provided to anchor each annotated NAT gene to the corresponding genomic
map; Column 11: Third-party annotation (TPA) accession numbers were assigned by the EMBL database and can be used to retrieve the complete
details of NAT genes in the table.
(c) Search of the EST
database additionally identified partial NAT-homologous sequences in the haptophyte Emiliania huxleyi (dbEST ID: FP203643), the
alveolate Karenia brevis (dbEST ID: EX962146), the
amoebozoon Acanthamoeba castellanii (dbEST ID: EC098681) and
the choanoflagellate Monosiga ovata (dbEST ID: DC473432).
Phylum |
Organism scientific name |
Organism identification code |
Taxonomy identifier |
Gene |
ORF (nt) |
Protein (aa) |
Exon span |
Number of introns |
Locus tag |
TPA accession number |
Microsporidia (4) |
NONE |
|
|
|
|
|
|
|
|
|
Chytridiomycota (2) |
Batrachochytrium dendrobatidis |
BATDE |
|
NAT1 |
897 |
298 |
1 (1-891) 2 (981-986) |
1 |
|
|
Blastocladiomycota (1) |
NONE |
|
|
|
|
|
|
|
|
|
Zygomycota (1) |
NONE |
|
|
|
|
|
|
|
|
|
Basidiomycota (16) |
Pucciniomycotina (2) |
|||||||||
Puccinia graminis f. sp. tritici CRL 75-36-700-3 |
PUCGR |
|
ΝΑΤ1 |
1008 |
335 |
1 (1-345) 2 (430-837) 3 (986-1240) |
2 |
|
|
|
Ustilaginomycotina (4) |
||||||||||
Malassezia globosa CBS 7966 |
MALGO |
|
ΝΑΤ1 |
834 |
277 |
1 (1-834) |
0 |
|
|
|
Ustilago maydis 521 |
USTMA |
|
ΝΑΤ1 |
1119 |
372 |
1 (1-102) 2 (177-1193) |
1 |
|
|
|
Agaricomycotina (10) |
||||||||||
Coprinus cinereus (Coprinopsis cinerea) okayama 7-130 |
COPC7 |
ΝΑΤ1 |
1089 |
362 |
1 (1-233) 2 (285-414) 3 (464-725) 4 (784-1247) |
3 |
|
|
||
ΝΑΤ2 |
1089 |
362 |
1 (1-230) 2 (287-415) 3 (493-749) 4 (831-1303) |
3 |
|
|
||||
Moniliophthora perniciosa FA553 |
CRIPE |
|
NAT1 |
459 (partial 3' end) |
153 (partial C-terminus) |
1 (1-459) |
0 |
|
|
|
Ascomycota (122) |
Taphrinomycotina (4) |
|||||||||
NONE |
|
|
|
|
|
|
|
|
|
|
Saccharomycotina (40) |
||||||||||
NONE |
|
|
|
|
|
|
|
|
|
|
Pezizomycotina (78) |
||||||||||
Ajellomyces capsulata G186AR |
AJECG |
|
ΝΑΤ1 |
963 |
320 |
1 (1-402) 2 (534-580) 3 (644-1157) |
2 |
|
|
|
Ajellomyces capsulata H88 |
AJEC8 |
|
ΝΑΤ1 |
963 |
320 |
1 (1-402) 2 (534-580) 3 (645-1158) |
2 |
|
|
|
Ajellomyces capsulata H143 |
AJECH |
|
ΝΑΤ1 |
963 |
320 |
1 (1-402) 2 (534-580) 3 (645-1158) |
2 |
|
|
|
Ajellomyces capsulata G217B |
AJECA |
|
ΝΑΤ1 |
963 |
320 |
1 (1-402) 2 (534-580) 3 (645-1158) |
2 |
|
|
|
Ajellomyces capsulata NAm1 |
AJECN |
|
ΝΑΤ1 |
963 |
320 |
1 (1-402) 2 (534-580) 3 (645-1158) |
2 |
|
|
|
Ajellomyces dermatitidis SLH14081 |
AJEDS |
|
ΝΑΤ1 |
963 |
320 |
1 (1-402) 2 (538-584) 3 (659-1172) |
2 |
|
|
|
Ajellomyces dermatitidis ER-3 |
AJEDR |
|
ΝΑΤ1 |
963 |
320 |
1 (1-402) 2 (538-584) 3 (659-1172) |
2 |
|
|
|
Alternaria brassicicola ATCC 96836 |
ALTBR |
|
ΝΑΤ1 |
924 |
307 |
1 (1-924) |
0 |
|
|
|
Aspergillus clavatus NRRL 1 |
ASPCL |
|
ΝΑΤ1 |
963 |
320 |
1 (1-410) 2 (462-507) 3 (581-1087) |
2 |
|
|
|
Aspergillus flavus NRRL-3357 |
ASPFN |
ΝΑΤ1 |
1017 |
338 |
1 (1-14) 2 (863-1865) |
1 |
|
|
||
ΝΑΤ2 |
981 |
326 |
1 (1-426) 2 (482-528) 3 (588-1095) |
2 |
|
|
||||
ΝΑΤ3 |
957 |
318 |
1 (1-396) 2 (450-1010) |
1 |
|
|
||||
ΝΑΤ4 |
641 |
possible pseudogene |
1 (1-92) 2 (144-692) |
1 |
|
|
||||
Aspergillus fumigatus CEA 10 / Af293 |
ASPFC |
|
ΝΑΤ1 |
990 |
329 |
1 (1-410) 2 (440-514) 3 (574-1078) |
2 |
|
|
|
Aspergillus |
ASPNC |
ΝΑΤ1 |
1047 |
348 |
1 (1-1047) |
0 |
||||
ΝΑΤ2 |
990 |
329 |
1 (1-441) 2 (508-1056) |
1 |
|
|
||||
ΝΑΤ3 |
948 |
315 |
1 (1-397) 2 (491-536) 3 (592-1096) |
2 |
|
|
||||
ΝΑΤ4 |
1050 |
349 |
1 (1-539) 2 (600-1110) |
1 |
|
|
||||
ΝΑΤ5 |
975 |
324 |
1 (1-975) |
0 |
|
|||||
Aspergillus terreus NIH 2624 |
ASPTN |
NAT1 |
957 |
318 |
1 (1-411) 2 (493-539) 3 (593-1091) |
2 |
|
|
||
NAT2 |
969 |
322 |
1 (1-393) 2 (448-1023) |
1 |
|
|
||||
Botryotinia fuckeliana B05.10 |
BOTFB |
|
NAT1 |
981 |
326 |
1 (1-380) 2 (470-1070) |
1 |
|
|
|
Chaetomium globosum CBS 148.51 |
CHAGB |
NAT1 |
927 |
308 |
1 (1-348) 2 (417-995) |
1 |
|
|
||
NAT2 |
984 |
327 |
1 (1-984) |
0 |
||||||
Coccidioides immitis H538.4 |
COCIT |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides immitis RS |
COCIM |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides immitis RMSCC 3703 |
COCIT |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides immitis RMSCC 2394 |
COCIT |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii C735 |
COCP7 |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii RMSCC 3488 |
COCPO |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii RMSCC 2133 |
COCPO |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii CPA 0020 |
COCPO |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii RMSCC 1038 |
COCPO |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii CPA 0001 |
COCPO |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii RMSCC 1037 |
COCPO |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Coccidioides posadasii str. Silveira |
COCPS |
|
NAT1 |
984 |
327 |
1 (1-411) 2 (473-1045) |
1 |
|
|
|
Emericella nidulans (Aspergillus nidulans) FGSC A4 |
EMENI |
|
ΝΑΤ1 |
960 |
319 |
1 (1-407) 2 (463-510) 3 (568-1072) |
2 |
|
|
|
Fusarium oxysporum f. sp. Lycopersici
4287 |
FUSO4 |
ΝΑΤ1 |
1053 |
350 |
1 (1-1053) |
0 |
||||
ΝΑΤ2 |
957 |
318 |
1 (1-372) 2 (424-1008) |
1 |
|
|
||||
ΝΑΤ3 |
999 |
332 |
1 (1-999) |
0 |
||||||
ΝΑΤ4 |
963 |
320 |
1 (1-366) 2 (549-1145) |
1 |
|
|
||||
Gibberella moniliformis (Fusarium
verticillioides) 7600 |
GIBM7 |
ΝΑΤ1 |
1038 |
345 |
1 (1-1038) |
0 |
||||
ΝΑΤ2 |
957 |
318 |
1 (1-957) |
0 |
||||||
ΝΑΤ3 |
978 |
325 |
1 (1-978) |
0 |
||||||
ΝΑΤ4 |
1011 |
336 |
1 (1-295) 2 (628-1024) 3 (1079-1397) |
2 |
|
|
||||
Gibberella zeae (Fusarium graminearum) RRL31084 |
GIBZE |
ΝΑΤ1 |
1032 |
343 |
1 (1-1032) |
0 |
||||
ΝΑΤ2 |
957 |
318 |
1 (1-372) 2 (431-1015) |
1 |
|
|
||||
ΝΑΤ3 |
960 |
319 |
1 (1-960) |
0 |
||||||
Glomerella graminicola M1.001 |
COLGM |
|
NAT1 |
927 |
308 |
1 (1-360) 2 (425-991) |
1 |
|
|
|
Magnaporthe grisea 70-15 |
MAGO7 |
ΝΑΤ1 |
963 |
320 |
1 (1-354) 2 (454-1062) |
1 |
|
|
||
ΝΑΤ2 |
1113 |
370 |
1 (1-1113) |
0 |
|
|||||
Microsporum canis CBS 113480 |
ARTOC |
|
ΝΑΤ1 |
1002 |
333 |
1 (1-422) 2 (486- 533) 3 (589-1120) |
2 |
|
|
|
Microsporum gypseum CBS 118893 |
ARTGP |
ΝΑΤ1 |
942 |
313 |
1 (1-416) 2 (585-1110) |
1 |
|
|
||
ΝΑΤ2 |
1008 |
335 |
1 (1-414) 2 (534-1127) |
1 |
|
|
||||
Nectria haematococca mpVI 77-13-4 |
NECH7 |
NAT1 |
891 |
296 |
1 (1-331) 2 (403-962) |
1 |
|
|
||
NAT2 |
966 |
321 |
1 (1-381) 2 (435-1019) |
1 |
|
|
||||
NAT3 |
897 |
298 |
1 (1-344) 2 (401-953) |
1 |
|
|||||
NAT4 |
1008 |
335 |
1 (1-1008) |
0 |
||||||
NAT5 |
930 |
309 |
1 (1-366) 2 (418-563) 3 (588-1005) |
2 |
|
|
||||
NAT6 |
960 |
319 |
1 (1-366) 2 (413-1006) |
1 |
|
|||||
Neosartorya fischeri (Aspergillus fischerianus) NRRL 181 |
NEOFI |
ΝΑΤ1 |
963 |
320 |
1 (1-410) 2 (467-514) 3 (574-1078) |
2 |
|
|
||
ΝΑΤ2 |
948 |
315 |
1 (1-378) 2 (436-1005) |
1 |
|
|
||||
Neurospora crassa OR74A |
NEUCR |
|
ΝΑΤ1 |
933 |
310 |
1 (1-333) 2 (402-1001) |
1 |
|
|
|
Paracoccidioides brasiliensis Pb01 |
PARBA |
|
ΝΑΤ1 |
951 |
possible pseudogene |
1 (1-402) 2 (527-573) 3 (641-1142) |
2 |
|
|
|
Paracoccidioides brasiliensis Pb03 |
PARBP |
|
ΝΑΤ1 |
951 |
316 |
1 (1-402) 2 (528-574) 3 (642-1143) |
2 |
|
|
|
Paracoccidioides brasiliensis Pb18 |
PARBD |
|
ΝΑΤ1 |
951 |
316 |
1 (1-402) 2 (527-573) 3 (641-1142) |
2 |
|
|
|
Penicillium chrysogenum |
PENCW |
NAT1 |
942 |
313 |
1 (1-396) 2 (522-1067) |
1 |
|
|
||
NAT2 |
972 |
323 |
1 (1-401) 2 (497-1067) |
1 |
|
|
||||
NAT3 |
948 |
315 |
1 (1-396) 2 (447-998) |
1 |
|
|
||||
Phaeosphaeria nodorum SN15 |
PHANO |
ΝΑΤ1 |
933 |
310 |
1 (1-933) |
0 |
||||
ΝΑΤ2 |
1053 |
350 |
1 (1-1053) |
0 |
||||||
Podospora anserina DSM980 |
PODAN |
NAT1 |
912 |
303 |
1 (1-342) 2 (401-970) |
1 |
|
|
||
NAT2 |
1002 |
333 |
1(1-1002) |
0 |
|
|||||
Pyrenophora tritici-repentis Pt-1C-BFP |
PYRTR |
ΝΑΤ1 |
1029 |
342 |
1 (1-1029) |
0 |
||||
ΝΑΤ2 |
924 |
307 |
1 (1-924) |
0 |
||||||
Sordaria macrospora k-hell |
SORMA |
|
NAT1 |
1101 |
366 |
1 (1-477) 2 (536-1159) |
1 |
|
|
|
Talaromyces stipitatus ATCC 10500 |
TALSN |
|
ΝΑΤ1 |
993 |
330 |
1 (1-438) 2 (555-1109) |
1 |
|
|
|
Trichoderma atroviride IMI 206040 |
HYPAI |
|
ΝΑΤ1 |
915 |
304 |
1 (1-339) 2 (417-992) |
1 |
|
|
|
Trichoderma reesei (Hypocrea jecorina)
QM6a |
HYPJQ |
|
ΝΑΤ1 |
918 |
305 |
1 (1-336) 2 (430-1011) |
1 |
|
|
|
Trichoderma virens (Hypocrea virens)
Gv29-8 |
HYPVG |
ΝΑΤ1 |
918 |
305 |
1 (1-333) 2 (426-1010) |
1 |
|
|
||
ΝΑΤ2 |
1026 |
341 |
1 (1-420) 2 (490-1095) |
1 |
|
|
||||
Trichophyton equinum CBS 127.97 |
TRIEC |
|
ΝΑΤ1 |
981 |
326 |
1 (1-416) 2 (481-528) 3 (593-1109) |
2 |
|
|
|
Trichophyton rubrum CBS 118892 |
TRIRC |
|
ΝΑΤ1 |
981 |
326 |
1 (1-416) 2 (481-528) 3 (593-1109) |
2 |
|
|
|
Trichophyton tonsurans CBS 112818 |
TRIT1 |
|
ΝΑΤ1 |
981 |
326 |
1 (1-416) 2 (481-528) 3 (593-1109) |
2 |
|
|
|
Uncinocarpus reesii UAMH 1704 |
UNCRE |
|
ΝΑΤ1 |
990 |
329 |
1 (1-417) 2 (467-1039) |
1 |
|
|
|
Verticillium albo-atrum VaMs.102 |
VERA1 |
|
ΝΑΤ1 |
762 |
253 |
1 (1-360) 2 (484-708) 3 (832-1008) |
2 |
|
|
|
Verticillium dahliae VdLs.17 |
VERDV |
ΝΑΤ1 |
951 |
316 |
1 (1-951) |
0 |
(a) The details and
provisional taxonomic classification of the sequenced fungal genomes are
available on http://www.ncbi.nlm.nih.gov/genomes/leuks.cgi and http://www.broadinstitute.org/science/projects/fungal-genome-initiative/current-fgi-sequence-projects.
These
fungal sequences have been described in detail in [41,42,43,44].
The reference sequence for annotation of fungal NATs is the NAT1 protein of the
ascomycetes Fusarium verticillioides (Gibberella moniliformis), GenBank ID: EU552489 [5,43].
(b) Column
key – Colums 1, 2: The numbers in brackets are sequenced fungal
genomes accessible via BLAST (2010). Search of the EST database additionally
retrieved a number of partial NAT-homologous
sequences (data not shown), all of which belong to either basidiomycetes or
ascomycetes (Pezizomycotina); Columns
2-4: The scientific name, official identification code and unique
taxonomy identifier for each organism are available from the UniProt Taxonomy
Browser (http://www.uniprot.org/taxonomy/); Columns 5-9:
The retrieval and annotation of NAT-homologous sequences (ORF
span and exon-intron structure) were carried out as described [41], and the gene symbols were assigned according to
the guidelines of the NAT Gene Nomenclature
Committee. The sequence length of open reading frames (ORF) is shown in nucleotides (nt) and of deduced proteins in amino acids (aa); Column 10:
Where validated, the locus tags are provided to anchor each annotated NAT gene to the corresponding genomic
map; Column 11: Third-party annotation (TPA) accession numbers were assigned by the EMBL database and can be used to retrieve the complete
details of the new NAT genes
described in this study.
METAZOA(b) |
||||||||
PLACOZOA |
||||||||
NONE |
||||||||
EUMETAZOA |
||||||||
Cnidaria |
||||||||
Acropora
millepora [mRNA sequence bearing
the complete ORF of a NAT-homologous
gene (GenBank ID:
EZ029316)] |
||||||||
Bilateria |
||||||||
Acoelomata
(Platyelminthes) |
||||||||
NONE |
||||||||
Pseudocoelomata
(Nematoda) |
||||||||
NONE |
||||||||
Coelomata |
||||||||
Protostomia |
||||||||
Mollusca |
||||||||
NONE |
||||||||
Panarthropoda |
||||||||
Arthropoda |
||||||||
Hexapoda (insects) |
||||||||
NONE |
||||||||
Organism scientific name(c) |
Organism identification code (c) |
Taxonomy identifier (c) |
Gene (alias) (c) |
ORF (nt) (c) |
Protein (aa) (c) |
Identities (%) |
Positives (%) |
Literature |
Deuterostomia |
||||||||
Echinozoa |
||||||||
Strongylocentrotus
purpuratus (purple sea urchin) |
STRPU |
|
933 |
310 |
27 |
44 |
||
|
654 |
217 |
24 |
42 |
||||
|
933 |
310 |
23 |
43 |
||||
Hemichordata |
||||||||
Saccoglossus kowalevskii (Acorn
worm) |
SACKO |
NAT1 |
903 |
300 |
20 |
38 |
||
Chordata |
|
|
|
|
|
|
|
|
Tunicata |
|
|
|
|
|
|
|
|
Ciona intestinalis (Transparent sea
squirt) |
CIOIN |
NAT1 |
789 ORF consists of 3 exons Exon 1: 1-335 Exon 2: 651-838 Exon 3: 1472-1737 (Gene size: 1737nt) |
262 |
28 |
45 |
||
NAT2 |
942 ORF consists of 5 exons Exon 1: 1-335 Exon 2: 685-866 Exon 3: 1863-1968 Exon 4: 3067-3157 Exon 5: 3624-3851 (Gene size: 3851nt) |
313 |
25 |
47 |
||||
Cephalochordata |
||||||||
Branchiostoma
floridae ( |
BRAFL |
NAT1 |
780 ORF consists of 4 exons Exon 1: 1-119 Exon 2: 639-957 Exon 3: 1238-1277 Exon 4: 1347-1648 (Gene size: 1648nt) |
259 |
30 |
48 |
41, |
|
NAT2 |
864 ORF consists of 3 exons Exon 1: 1-119 Exon 2: 1713-2037 Exon 3: 2282-2701 (Gene size: 2701nt) |
287 |
27 |
48 |
41, |
|||
NAT3 |
909 ORF consists of 3 exons Exon 1: 1-176 Exon 2: 779-906 Exon 3: 4565-5169 (Gene size: 5169nt) |
302 |
23 |
42 |
||||
Vertebrata |
||||||||
Chondrichthyes |
||||||||
NONE |
||||||||
Euteleostomi |
||||||||
Actinopterygii |
||||||||
Danio rerio (zebrafish) |
DANRE |
|
867 |
288 |
43 |
62 |
||
|
867 |
288 |
42 |
62 |
||||
|
867 |
288 |
42 |
61 |
||||
|
873 |
290 |
40 |
59 |
||||
Gasterosteus aculeatus (three-spined stickleback) |
GASAC |
|
912 |
303 |
42 |
62 |
||
|
870 |
289 |
41 |
61 |
||||
Oryzias latipes (medaka fish) |
ORYLA |
|
873 |
290 |
44 |
61 |
||
|
873 |
290 |
40 |
61 |
||||
|
846 |
281 |
35 |
52 |
||||
Takifugu (Fugu)
rubripes (Japanese pufferfish) |
TAKRU |
|
846 |
281 |
33 |
50 |
||
Tetraodon nigroviridis (green spotted pufferfish) |
TETNG |
|
843 |
280 |
34 |
49 |
||
Sarcopterygii |
||||||||
Amniota |
||||||||
Mammalia (d) |
||||||||
Primates (e) |
||||||||
Allenopithecus
nigroviridis (Allen’s swamp monkey) |
ALLNI |
|
873 |
290 |
94 |
98 |
||
|
873 |
290 |
82 |
90 |
||||
Cebus
apella (Brown-capped capuchin monkey) |
CEBAP |
|
873 |
290 |
94 |
98 |
||
|
873 |
290 |
81 |
90 |
||||
Cercopithecus
diana (Diana monkey) |
CERDI |
|
873 |
290 |
95 |
98 |
||
|
873 |
290 |
82 |
90 |
||||
Colobus
guereza (black and white colobus monkey) |
COLGU |
|
873 |
290 |
95 |
99 |
||
|
873 |
290 |
82 |
89 |
||||
Chlorocebus
tantalus (tantalus monkey) |
CERTA |
|
873 |
290 |
96 |
99 |
||
|
873 |
290 |
82 |
89 |
||||
Erythrocebus
patas (Red
guenon) |
ERYPA |
|
873 |
290 |
96 |
99 |
||
|
873 |
290 |
82 |
90 |
||||
Gorilla
gorilla (Lowland gorilla) |
GORGO |
|
873 |
290 |
98 |
99 |
||
|
873 |
290 |
82 |
89 |
||||
Homo sapiens (human) |
HUMAN |
|
873 |
290 |
100 |
100 |
||
|
873 |
290 |
81 |
89 |
||||
Hylobates
lar (White handed gibbon) |
HYLLA |
|
873 |
290 |
96 |
99 |
||
|
873 |
290 |
81 |
88 |
||||
Presbytis
cristatus (silvered-leaf monkey) |
TRACR |
|
873 |
290 |
96 |
99 |
||
|
873 |
290 |
82 |
90 |
||||
Macaca fascicularis
(Crab-eating macaque) |
MACFA |
|
873 |
290 |
94 |
98 |
||
|
873 |
290 |
82 |
89 |
||||
Macaca
mulatta (Rhesus
macaque) |
MACMU |
|
873 |
290 |
94 |
99 |
||
|
873 |
290 |
82 |
90 |
||||
Macaca
sylvanus (Barbary ape) |
MACSY |
|
873 |
290 |
95 |
99 |
||
|
873 |
290 |
82 |
90 |
||||
Mandrillus
sphinx (Mandrill) |
MANSP |
|
873 |
290 |
95 |
99 |
||
|
873 |
290 |
82 |
89 |
||||
Microcebus
murinus
(gray mouse lemur) |
MICMU |
|
873 |
290 |
80 |
90 |
||
|
873 |
290 |
74 |
85 |
||||
Nomascus
gabriellae (Red cheeked gibbon) |
NOMGA |
|
873 |
290 |
96 |
99 |
||
|
873 |
290 |
82 |
89 |
||||
Otolemur
garnettii
(small-eared galago) |
OTOGA |
NAT1 |
873 |
290 |
82 |
93 |
||
Pan
paniscus (Pygmy chimpanzee) |
PANPA |
|
873 |
290 |
98 |
100 |
||
NAT2 |
873 |
290 |
81 |
89 |
||||
Pan
troglodytes (chimpanzee) |
PANTR |
|
873 |
290 |
97 |
100 |
||
|
873 |
290 |
81 |
89 |
||||
Papio
anubis (Olive baboon) |
PAPAN |
|
873 |
290 |
95 |
99 |
||
|
873 |
290 |
82 |
89 |
||||
Pithecia
pithecia (White faced saki) |
PITPI |
|
873 |
290 |
95 |
99 |
||
|
873 |
290 |
82 |
91 |
||||
Pongo
abelii (Sumatran orangutan) |
PONAB |
|
873 |
290 |
96 |
99 |
||
|
873 |
290 |
81 |
89 |
||||
Saimiri
boliviensis boliviensis (Bolivian squirrel monkey) |
SAIBB |
|
873 |
290 |
93 |
97 |
|
|
Other mammals |
||||||||
Bos taurus (domestic cattle) |
BOVIN |
|
873 |
290 |
82 |
93 |
||
Cavia
porcellus (domestic
Guinea pig) |
CAVPO |
Nat1 |
870 |
289 |
79 |
91 |
||
Nat2 |
873 |
290 |
81 |
93 |
||||
Nat3 |
873 |
290 |
71 |
86 |
||||
Cricetulus griseus (Chinese hamster) |
CRIGR |
Nat2 |
873 |
290 |
80 |
92 |
||
Echinops
telfairi (lesser
hedgehog tenrec) |
ECHTE |
|
873 |
290 |
80 |
88 |
||
Equus caballus (domestic horse) |
HORSE |
|
873 |
290 |
82 |
92 |
||
Loxodonta Africana (African bush elephant) |
LOXAF |
|
873 |
290 |
84 |
93 |
||
|
873 |
290 |
82 |
91 |
||||
|
873 |
290 |
77 |
87 |
||||
Mesocricetus auratus (Syrian hamster) |
MESAU |
Nat1 |
873 |
290 |
71 |
83 |
||
Nat2 |
873 |
290 |
81 |
92 |
||||
Monodelphis domestica (gray
short-tailed opossum) |
MONDO |
|
870 |
289 |
68 |
85 |
||
Mus musculus (house mouse) |
MOUSE |
Nat1 |
873 |
290 |
74 |
85 |
||
Nat2 |
873 |
290 |
82 |
94 |
||||
Nat3 |
873 |
290 |
68 |
81 |
||||
Myotis lucifugus (little brown bat) |
MYOLU |
|
873 |
290 |
82 |
92 |
||
|
873 |
290 |
73 |
86 |
||||
Ornithorhynchus
anatinus (platypus) |
ORNAN |
|
870 |
289 |
56 |
73 |
||
Oryctolagus cuniculus (European rabbit) |
RABIT |
|
873 |
290 |
75 |
87 |
||
|
873 |
290 |
74 |
87 |
||||
|
|
|
|
870 |
289 |
81 |
88 |
|
Rattus norvegicus (brown rat) |
RAT |
Nat1 |
873 |
290 |
76 |
87 |
||
Nat2 |
873 |
290 |
81 |
93 |
||||
Nat3 |
873 |
290 |
68 |
81 |
||||
Sus scrofa (pig) |
PIG |
|
873 |
290 |
84 |
92 |
||
Sauria |
||||||||
Lepidosauria |
||||||||
Anolis carolinensis ( |
ANOCA |
|
867 |
288 |
54 |
72 |
||
|
867 |
288 |
53 |
72 |
||||
|
816 |
271 |
35 |
50 |
||||
Archosauria |
||||||||
Aves |
||||||||
Gallus gallus (chicken) |
CHICK |
|
873 |
290 |
57 |
76 |
||
|
873 |
290 |
53 |
72 |
||||
|
873 |
290 |
53 |
72 |
||||
|
852 |
283 |
48 |
71 |
||||
Taeniopygia
guttata (Zebra finch) |
|
|
873 |
290 |
59 |
76 |
||
|
873 |
290 |
53 |
71 |
||||
|
867 |
288 |
52 |
70 |
||||
|
891 |
296 |
50 |
70 |
(a)
The reference sequence for annotation of animal NATs is the NAT1 protein of Homo sapiens
(Human), GenBank ID: X17059 [9,10]. Amino acid sequence homology (identity and similarity) is calculated
relative to this reference sequence.
(b)
Search of the EST database identified partial NAT sequences from additional metazoa, including the rotifer Brachionus
plicatilis (dbEST ID:
FM940182), the mollusc Lottia
gigantea (dbEST ID:
FC756210), the crustacean Litopenaeus
vannamei (dbEST ID:
FE155086), the insect Adelphocoris
lineolatus (dbEST ID:
GR483776), the asterozoon Patiria
pectinifera (dbEST
ID: DB395455), the salamander Cynops
pyrrhogaster (dbEST
ID: FS311170), and the frogs Xenopus
laevis (dbEST ID:
EB646873) and Xenopus (Silurana)
tropicalis (dbEST ID:
EL679494) [41]. An additional sequence has been reported in
Felis
silvestris catus [26]. NAT activity has also been
detected in the domestic pigeon Columba livia, but no gene sequence is
yet available [27,28]. NAT genes are absent
in the genome of the domestic dog Canis familiaris [29]. NAT activity has been reported in some
nematodes [6,7], but the results are not verified as
yet.
(c)
Official organism scientific names, identification codes and
taxonomy identifiers are from the NEWT
UniProt Taxonomy Browser. Taxonomic presentation is according to the NCBI Taxonomy
Database, which provides a platform for the classification of all organisms
represented in the GenBank database. Please note that these databases are
not a primary source for taxonomic or phylogenetic information and
should not be used as such. Abbreviations:
ORF – open reading frame; nt – nucleotides; aa – amino acids.
(d)
A number of upstream non-coding exons have been reported in the
literature for the NAT genes of the primates [11,30-36],
rodents [12,15,16,37-39] and chicken [2]. The complex structure of vertebrate NAT genes
is reviewed in references [2,40].
(e)
Pseudogenes with homology to NAT genes (designated NATP1) have been identified in the
primates Homo sapiens, Colobus guereza, Presbytis cristatus, Allenopithecus
nigroviridis, Cercopithecus diana,
Chlorocebus tantalus, Erythrocebus patas, Mandrillus sphinx, Macaca
sylvanus, Macaca mulatta, Nomascus gabriellae, Gorilla gorilla, Pan troglodytes, Pan paniscus
[46].
All reported
sequences are stored in electronic format and can be requested from the curator
of this website. Please note that many of the ORFs
described in the above tables were reconstructed
from draft low homology genomic sequences retrieved during our
database searches. Therefore, these sequences represent only putative NAT
genes and each ORF should be checked for possible inaccuracies in length
and sequence before any further study is undertaken.
If you wish to
acknowledge this website as a source of data in future publications, please
cite references [1 and 41].
For new
submissions or enquiries, please contact Dr. Sotiria Boukouvala (sboukouv@mbg.duth.gr).
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